Muscle fibrosis and contractures in a pethidine addict.

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Muscle fibrosis and contractures in a pethidine addict.

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Biological and Biomechanical Changes in Muscle Contractures

Background: Cerebral palsy (CP) is an upper motor neuron disease that results in a progressive movement disorder. Secondary to the neurological insult, muscles from CP patients often become spastic. Spastic muscle is characterized by an increased resistance to stretch, but often develops the further complication of contracture which represents a prominent disability in children with CP. This st...

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Pethidine | Pethidine Addiction | Pethidine Withdrawal

Pethidine is indicated for the treatment of moderate to severe pain, and is delivered as its hydrochloride salt in tablets, as a syrup, or by intramuscular or intravenous injection. For much of the 20th century, pethidine was the opioid of choice for many physicians; in 1983 60% of doctors prescribed it for acute pain and 22% for chronic severe pain. Compared to morphine, pethidine was supposed...

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Biphasic Potassium Contractures in Frog Muscle Fibers

Potassium-induced contractures were studied in single fibers from the semitendinosus muscle of Rana pipiens. Contractures elicited by solutions containing 60-117 mM potassium and 120 mM chloride were biphasic, consisting of a rapid initial contraction with a duration at 23 degrees C of less than 1 sec followed by a slow response with a duration of many seconds. At 13 degrees C, the initial resp...

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Pethidine | Pethidine Addiction | Pethidine Withdrawal

Pethidine is indicated for the treatment of moderate to severe pain, and is delivered as its hydrochloride salt in tablets, as a syrup, or by intramuscular or intravenous injection. For much of the 20th century, pethidine was the opioid of choice for many physicians; in 1983 60% of doctors prescribed it for acute pain and 22% for chronic severe pain. Compared to morphine, pethidine was supposed...

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ژورنال

عنوان ژورنال: BMJ

سال: 1971

ISSN: 0959-8138,1468-5833

DOI: 10.1136/bmj.4.5786.532